TABLE 1

Experimentally resolved structures of Cys-loop ion channels

Summary of the principal structures of prokaryote and eukaryote receptors obtained by X-ray diffraction (XRD), electron cryomicroscopy (ECM), or solution nuclear magnetic resonance (NMR). Additionally, the states of the ion channel in each structure are indicated—open (O), closed (C), locally closed (LC), resting (R) states, or not applicable (NA)—with corresponding codes of the Protein DataBank (http://www.rcsb.org/pdb/home/home.do).

ReceptorStructureStateMethodReferenceRelease
ELIC2VL0: 3.3 ÅCXRDHilf and Dutzler, 20082008
3RQU: 3.09 ÅCPan et al., 2012b2012
ELIC F246A mutant2YKS: 3.30 ÅCXRDZimmermann and Dutzler, 20112011
ELIC F16ʹS mutant4TWH: 3.60 ÅCXRDUlens et al., 20142014
ELIC L9ʹ F16ʹ double mutant3UQ5: 4.2 ÅOXRDGonzalez-Gutierrez et al., 20122012
3UQ7: 3.8 Å
GLIC3EAM: 2.90 ÅOXRDBocquet et al., 20092008
3EHZ: 3.10 ÅOHilf and Dutzler, 20092008
4HFI: 2.4 ÅOSauguet et al., 2013b2013
4NPQ: 4.35 ÅRSauguet et al., 20142013
GLIC H11ʹF mutant3TLT: 3.3 ÅLCXRDPrevost et al., 20122012
GLIC E19ʹP mutant3TLS: 3.2 ÅLCXRDPrevost et al., 20122012
GLIC F14ʹA mutant4HFB: 2.75 ÅOXRDSauguet et al., 2013a2013
GLIC I9ʹA T25ʹA double mutant4LML: 3.8 Å (lig-bounded)CXRDGonzalez-Gutierrez et al., 20132013
GluCl3RHW: 3.26 ÅOXRDHibbs and Gouaux, 20112011
4TNV: 3.60 ÅCAlthoff et al., 20142014
nAChR 2αβδγ2BG9: 4 ÅCECMUnwin, 20052005
4AQ9: 6.2 ÅOUnwin and Fujiyoshi, 20122012
4AQ5: 6.2 ÅCUnwin and Fujiyoshi, 20122012
nAChR α7 (TMs)2MAWNANMRMowrey et al., 2013b2013
5-HT3A4PIR: 3.5 ÅOXRDHassaine et al., 20142014
GABAA β34COF: 2.97 ÅCXRDMiller and Aricescu, 20142014
GlyR α13JAE: 3.9 ÅOECMDu et al., 20152015
3JAD: 3.9 ÅC
GlyR α35CFB: 3.04 ÅCXRDHuang et al., 20152015
GlyR α1 (TMs)2M6BNANMRMowrey et al., 2013a2013
2M6IO
GlyR α1 (TM2–TM3)1VRYNANMRMa et al., 20052005
Chimera GlyR-GLIC4X5T: 3.5 ÅCXRDMoraga-Cid et al., 20152015
Chimera ELIC-GLIC4YEU: 4.60 ÅRXRDUnpublished2015