TABLE 1
Examples of mGlu5 receptor synthetic ligands
| Chemical Compound | Structure | Target Receptor | Reference |
|---|---|---|---|
| 3,5-Dihydroxyphenylglycine (DHPG) |  | mGlu1/5 receptor agonist | Ito et al. (1992) |
| (RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) |  | mGlu5 receptor agonist | Doherty et al. (1997) |
| 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) |  | mGlu5 receptor PAM | Kinney et al. (2005) |
| 2-Methyl-6-(phenylethynyl)-pyridine (MPEP) |  | mGlu5 receptor NAM (inverse agonist) | Gasparini et al. (1999) |
| 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP) |  | mGlu5 receptor NAM (inverse agonist) | Cosford et al. (2003) |
| 2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine (CTEP) |  | mGlu5 receptor NAM (inverse agonist) | Lindemann et al., (2011) |
NAM, negative allosteric modulator; PAM, positive allosteric modulator.