TABLE 2
Examples of synthetic ligands of the endocannabinoid system
| Chemical Compound | Structure | Target Receptor | Reference |
|---|---|---|---|
| Arachidonyl-2-chloroethylamide (ACEA) |  | CB1 receptor agonist | Hillard et al. (1999) |
| (R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl) pyrrolo[1,2,3,-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate (WIN 55,212-2) |  | CB1 receptor agonist | Di Marzo (2009) |
| 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(1-piperidyl)pyrazole-3-carboxamide (AM251) |  | CB1 receptor antagonist (inverse agonist) | Di Marzo (2009) |
| Cyclohexyl carbamic acid 3′-carbamoyl-biphenyl-3-yl ester (URB597) |  | FAAH inhibitor | Mor et al. (2004) |
| 4-Nitrophenyl-4-[bis(1,3-benzodioxol-5-yl)(hydroxy)methyl]piperidine-1-carboxylate (JZL 184) |  | MAGL inhibitor | Long et al. (2009) |