Vehicle | PF-06649298 5 μM | PF-06649298 2 μM | PF-06761281 2 μM | PF-06761281 1 μM | |
---|---|---|---|---|---|
IC50 (μM) | 745 ± 111 | 196 ± 3**** | 422 ± 36** | 112 ± 11**** | 226 ± 12*** |
Hill slope | 2.25 ± 0.12 | 1.02 ± 0.02 | 0.86 ± 0.04 | 0.97 ± 0.02 | 1.3 ± 0.06 |
Data are averages ± S.E.M. from three independent experiments with P values.
↵** P < 0.01; *** P < 0.001; **** P < 0.0001, one-way ANOVA with Dunnett post hoc test.