Pharmacokinetic parameters of compounds I and II in comparison with efavirenz in BALB/c mice
Data are the mean ± S.D. values of triplicate measurements; n represents the number of mice.
| Pharmacokinetic Parameter | Compound I (n = 3) | Compound II (n =3) | Efavirenza (n = 3) |
|---|---|---|---|
| Dose (mg/kg) | 20 | 20; 100 | 20 |
| Cmax (µg/ml) | 0.54 ± 0.02 | 11.8 ± 0.7; 52.3 ± 5.7 | 1.8 ± 0.6 |
| Tmax (hour) | 4 | 4; 4 | 4 |
| AUC0–last (µg/h/ml) | 13.1 ± 0.4 | 201.7 ± 23.4; 896.4 ± 50.71 | 20.4 ± 21.1 |
| CL (ml/min/kg) | 25.4 | 1.6; 1.8 | 16.3 |
Tmax, time taken to reach Cmax.
↵a Destache et al. (2010).