TABLE 1

HIV-RT inhibitory activity (IC50 in nM), experimental aqueous solubility (in µg/ml) at pH 6.5, and computed C log P

Data are the mean ± S.D. values from three different experiments involving triplicate measurements.

CompoundWTC log PSolubility
nmµg/ml
I4.2 ± 0.73.38510a
II2.0 ± 0.43.8482.9
Rilpivirine1.5 ± 0.45.750.02b; 0.24c
Efavirenz41 ± 2d4.67a68a
  • a Lee et al. (2014).

  • b Janssen et al. (2005), pH 7.

  • c Sun et al. (2012), pH 7.4.

  • d King et al. (2002).