Targets | Therapeutic agents | Targeting ligands | Cell lines | Results | References |
---|---|---|---|---|---|
Integrins | RGD modified and Dox-loaded selenium nanoparticles | RGD | HUVECs and MCF-7 breast cancer cells | Selectively binding to tumor vessel and achieving antiangiogenesis. | Fu et al., 2016 |
c(RGDfk) mediated nanoparticle encapsulatedVEGFR2-siRNA | C(RGDfk) | HUVECs and A549 lung cancer cells | Inducing effective gene silence in vitro and inhibiting tumor growth in vivo | Liu et al., 2014 | |
Neuropilin-1 | Peptide modified liposome loaded with Dox | ATWLPPR peptide | B16-F1 murine melanoma cells | Increased tumor targeting and suppressed tumor growth | Herringson and Altin, 2011 |
gC1qR | LyP-1 conjugated to PEGylated liposomes loaded with or Dox | Lyp-1 | SPC-A1 lung adenocarcinoma cells | Enhanced inhibition effect on tumor cells in vitro and lymphatic metastatic tumors in vivo | Yan et al., 2012 |
M2-like TAM | Nanoformulations composed of (RNAi)-peptide biohybrid | M2pep | Mouse BALB/c macrophage J774.2 cells | Immunomodulating TAMs in tumor microenvironment and efficaciously eradicating tumor cells | Conde et al., 2015 |
HUVEC, human umbilical vein endothelial cell.