TABLE 1

Known compounds targeting TRPV3 channels

Compound	Activate	Inhibit	Description/Use	Reference
2-APB	TRPV1/TRPV2/TRPV3/TRPV6	TRPC6/TRPM8	Inhibitor of store-operated Ca²⁺ influx and IP₃-mediated Ca²⁺ release; common regulator of TRP channels	Chung et al., 2004; Hu et al., 2004
Camphor	TRPV1/TRPV3	TRPA1	Modulate sensations of warmth in humans	Moqrich et al., 2005; Xu et al., 2005
Menthol	TRPV3/TRPM8/TRPA1	TRPA1	Cooling effect; modulation of warm sensation	Macpherson et al., 2006
Cinnamaldehyde	TRPV3/TRPA1	TRPM8	Used as a spice	Macpherson et al., 2006
Carvacrol	TRPV3/TRPA1		Rapidly desensitizes TRPA1; present in oregano, which is used as a spice	Xu et al., 2006
Eugenol	TRPV3/TRPA1		Present in clove, which is used as a spice; lingual irritation; innocuous warmth and pain in response to heat	Schöll and Jensen-Jarolim, 2004; Xu et al., 2006
Thymol	TRPV3/TRPA1/TRPM8		Derived from thyme, which is used as a spice	Xu et al., 2006
Incensole acetate	TRPV3		A novel anxiolytic and antidepressive agent	Moussaieff et al., 2008
FPP	TRPV3		First identified endogenous TRPV3 activator; causes nociception	Bang et al., 2010
IPP		TRPV3/TRPA1	Endogenous inhibitor; a precursor molecule for FPP synthesis in the mevalonate pathway	Bang et al., 2011
Drofenine	TRPV3		Antispasmodic agent; 2-APB analog; improved selectivity for TRPV3	Deering-Rice et al., 2014
DPBA	TRPV1/TRPV2/TRPV3/TRPV4		2-APB structural analogs	Chung et al., 2005
DPTHF		TRPV1/TRPV2/ TRPV3	2-APB structural analogs	Chung et al., 2005
Nicotinic acid	TRPV1/TRPV3	TRPV2/TRPV4	Used to treat dyslipidemias but causes a side effect of cutaneous vasodilation, commonly called flushing	Ma et al., 2015
17R-RvD1		TRPV3	Proresolving lipid	Bang et al., 2012
Icilin	TRPM8	TRPV3	Super cooling agent	Sherkheli et al., 2012

DPBA, diphenylboronic anhydride; DPTHF, diphenyltetrahydrofuran; FPP, farnesyl pyrophosphate; IP₃, inositol trisphosphate; IPP, isopentenyl pyrophosphate.