Time course of auditory brainstem response thresholds for WT control and isoform-specific NO-GC KO mice
| Noise-ABR Threshold (dB SPL) | |||
|---|---|---|---|
| Before Noise Exposure | ∼30 min After Noise Exposure | 7 Days After Noise Exposure | |
| NO-GC WT n = 7–12 ears,4–6 mice | 8.0 ± 4.3 S.D. | 63.9 ± 9.7 S.D.** | 46.0 ± 9.5 S.D.* |
| NO-GC1 KO n = 7–14 ears, 4–7 mice | 6.4 ± 3.3 S.D. | 61.8 ± 10.3 S.D.** | 34.5 ± 6.6 S.D.** |
| NO-GC2 KO n = 8–12 ears, 4–6 mice | 9.2 ± 3.4 S.D. | 59.7 ± 14.6** | 33.7 ± 12.1 S.D.** |
| One-way ANOVA | P = 0.4002 | P = 0.8784 | P = 0.0663 |
↵* P < 0.05, **P < 0.01, two-sided paired Student’s t-test, comparisons between before noise exposure vs. ∼30 minutes after noise exposure and before noise exposure vs. 7 days after noise exposure.