TABLE 1 

Inhibition of histamine-evoked Ca2+ signals by PGE2 and cAMP

Cells were incubated for the times shown with the indicated drugs before recording the peak increase in [Ca2+]i evoked by histamine (3 μM; 1 mM for forskolin and NKH 477). Results (means ± S.E.M. from n independent experiments) show the maximal inhibition of the histamine-evoked Ca2+ signals and the pIC50 for each drug.

pIC50Maximal inhibition n
/M%
PGE2 (5 min)9.01 ± 0.0564 ± 49
Butaprost (5 min)7.28 ± 0.0961 ± 16
L902,688 (5 min)9.35 ± 0.1076 ± 45
8-Br-cAMP (20 min)2.98 ± 0.2085 ± 33
6-Bnz-cAMP (20 min)3.73 ± 0.1464 ± 55
Forskolin (5 min)6.24 ± 0.1157 ± 64
NKH 477 (5 min)5.50 ± 0.1853 ± 45