TABLE 2

Plasma concentrations of E6130 after oral administration in mice

Data are shown as the mean values ± S.E.M. (n = 3–6). Plasma protein binding of E6130 in mice: 93.3%.

DosePlasma Concentration (nM)
3026
mg/kgminh
10236 ± 57.326.4 ± 11.610.7 ± 5.24
301430 ± 23765.8 ± 12.622.8 ± 15.9