TABLE 6

RVX-297 decreases ex vivo cytokine production by lymphocytes isolated from EAE mice

Lymphocytes were isolated from EAE mice treated with RVX-297 (n = 3) or vehicle (n = 3) for 11 days. Independent cultures established from each mouse were rechallenged with MOG peptides 35–55 for 72 hours and secreted cytokine levels determined through cytometric bead assays run in triplicate. Data represent the mean percent reduction in cytokines produced by cells from RVX-297–treated mice compared with cells from vehicle-treated controls, with variability presented as the S.D. Statistical significance was determined with a Student’s t test.