TABLE 3

RVX-297 decreases cytokine gene expression and protein levels in the ankle of the rCIA model

Percent reduction in gene expression (n = 7) or protein levels (n = 4) in the ankle of rCIA animals treated with 75 mg/kg BID RVX-297 vs. vehicle-treated controls. Data are shown as the mean ± S.D. Statistical significance compared with the vehicle-treated controls was determined using a Student’s t test.

GeneReduction in Gene Expression in Ankles (%)ProteinReduction in Ankle Joint Protein (%)
IL-1β77 ± 16***IL-652 ± 28*
MMP360 ± 21***VCAM-133 ± 4***
MMP1337 ± 16***
RANKL70 ± 6***
  • * P < 0.05; ***P < 0.001.