Mouse cardiomyocyte contractility
| Concentration | CCG224061 | ||
|---|---|---|---|
| DMSO | 0.5 μM | 1 μM | |
| Baseline before isoproterenol | |||
| Max contraction (% cell length) | 4.6 ± 0.7 | 4.5 ± 0.8 | 6.4 ± 0.6 |
| After isoproterenol | |||
| Max contraction (% cell length) | 11 ± 1.7 | 16 ± 1.1 | 17 ± 1.2* |
| % Increase in contraction | 150 ± 45 | 280 ± 92 | 180 ± 26 |
Values represent the mean contraction amplitude (as a percentage of cell length) ± S.E.M. for six to eight cardiomyocytes. Statistical significance (*P < 0.05) was determined in comparison with the dimethylsulfoxide (DMSO) control by a one-way ANOVA followed by Dunnett’s test.