↵* P < 0.05 for log EC₅₀ values compared with same day controls (ANOVA, Bonferroni post-hoc test; F_8,86 = 97.14). Power to detect an effect size of 0.5 was 0.94.

Concentration-effect curves for PYD-106 were generated for GluN2C mutations and fitted by the Hill equation (see Materials and Methods). The mean EC₅₀ and mean fitted maximum response as a percent of control (95% CI determined from log EC₅₀) are given. N is the number of oocytes, which were isolated from two to four different frogs. N.D., the EC₅₀ could not be determined because either there was no effect of PYD-106 or the maximal potentiation was not obtained in the concentration range tested.