mGlu2 affinities (Ki) of mGlu2 PAMs and NAMs determined by [3H]-AZ12559322 displacement experiments
Data represent the mean ± S.E.M. of three individual experiments performed in triplicate.
| Allosteric Modulator | Log Ki (Ki) |
|---|---|
| nM | |
| BINA | −8.35 ± 0.11 (4.5) |
| AZD8418 | −7.59 ± 0.10 (28.2) |
| JNJ-42491293 | −9.12 ± 0.07 (0.77) |
| Decoglurant | −8.55 ± 0.18 (2.85) |
| VU6001192 | −6.87 ± 0.08 (136) |
| MNI-137 | −7.53 ± 0.09 (29.3) |
| MRK-8-29 | −8.54 ± 0.11 (2.91) |