TABLE 3

Change in APD90 in response to varying drug kinetics of block

AP simulations were run with rates calculated from 22°C and 36°C experimental data or with scalars applied to 22°C calculated rates. The change in APD90 is expressed as the difference between AP data in the presence and absence of drug under the listed conditions.

ΔAPD90
22°C36°C×2 kon, koff×7 kon, koff×2 kon, ×7 koff×7 kon, ×2 koff
msmsmsmsmsms
300 nM verapamil44−64555−20196
30 nM cisapride29732929892
100 nM bepridil3771384312121
10 nM terfenadine75204878928234