TABLE 1

Group denominations of HDM allergens, with exemplars, and their bioactivity profiles based on bioinformatics predictions and/or empirical observations

The list omits storage mite species exemplars of the subclass Acari, although in many cases their allergens show the same grouping and characteristics as the HDM allergens. Exemplar GenBank and UniProt accession codes of the listed allergens are provided for supporting literature references and bioinformatics substantiation (e.g., by hyperlink to simple modular architecture research tool “SMART”), but codes for isoallergenic variants are omitted for brevity.

HDM Allergen Group ExemplarsMolecular MassKnown or Predicted BioactivityGenBank/EMBLUniProt
kDa
Group 1, e.g., Der p 125 (39 Blo t 1)Cysteine proteaseU11695P08176
Der f 1AB03496Q58A71
Eur m 1AF047610P25780
Der m 1—P16312
Blo t 1AF277840Q95PJ4
Group 2, e.g., Der p 214NPC2 family; MD-2–related protein, lipid binding, binds LPSAF276239P49278
Der f 2D10447Q00855
Eur m 2AF047613Q9TZZ2
Blo t 2AY288141Q1M2P1
Group 3, e.g., Der p 325TrypsinU11719P39675
Der f3D63858P49275
Eur m3AF047615O97370
Blo t 3AY291323A1KXI1
Group 4, e.g., Der p 460AmylaseAF144060Q9Y197
Der f 4KM016832A0A089FLV3
Eur m 4AF144061Q9Y196
Blo t 4AY291324A1KXI2
Group 5, e.g., Der p 514Function unknown; ligand-binding protein?S76337P14004
Blo t 5U59102O96870
Group 6, e.g., Der p 625Chymotrypsin—P49277
Der f 6AF125187P49276
Blo t 6AY291325A1KXI3
Group 7, e.g., Der p 726–31Bactericidal permeability-increasing like protein of unknown function; belongs to the juvenile hormone binding family of proteins found in insects; may have lipid-binding propertiesU37044P49273
Der f 7S80655Q26456
Blo t 7MF740745—
Group 8, e.g., Der p 827Glutathione S-transferaseS75286P46419
Der f 8KC305499L7V2G7
Blo t 8GQ398117C8CGT7
Group 9, e.g., Der p 929Collagenase-like serine proteaseAY211952Q7Z163
Group 10, e.g., Der p 1036TropomyosinY14906O18416
Der f 10D17682Q23939
Blo t 10EU106615A7XZI4
Group 11, e.g., Der p 11103ParamyosinAY189697Q6Y2F9
Der f 11AF352244Q967Z0
Blo t 11AF525465Q8MUF6
Group 12, e.g., Blo t 1214Possible chitinase; shows homology with Der f 15 due to chitin-binding domainU27479Q17282
Group 13, e.g., Der p 1315Fatty acid–binding proteinHM560018E0A8N8
Der f 13AY283293Q1M2P5
Blo t 13U58106Q17284
Group 14, e.g., Der p 14177Vitellogenin or lipophorinAF373221Q8N0N0
Der f 14D17686Q94507
Eur m14AF149827Q9U785
Group 15, e.g., Der p 1598, 109aGH18 superfamily chitinase; shows homology with mite group 18.DQ078741Q4JK69
Der f 15AF178772Q9U6R7
Group 16, e.g., Der f 1653Gelsolin/villinAF465625Q8MVU3
Group 17, e.g., Der f 1730Calcium-binding protein——
Group 18, e.g., Der p 1860GH18 superfamily chitinase; homologous with group 15DQ078739Q4JK71
Der f 18AY093656Q86R84
Group 19, e.g., Blo t 197Antimicrobial peptide homologyKF771884W5RZ24
Group 20, e.g., Der p 2040Arginine kinaseEU684970B2ZSY4
Der f 20KM009994.1—
Group 21, e.g., Der p 2114Function unknown; shows homology with group 5 allergensDQ354124Q2L7C5
Der f 21KF732965.1B2GM84
Blo t 21DQ788679A7IZF1
Group 22, e.g., Der f 2217Shows homology with group 2 mite allergen; belongs to MD-2–related lipid recognition domain family; implicated in lipid bindingDQ643992A5X5X4
Group 23, e.g., Der p 2314–19Unknown function; shows homology with peritrophin-A domain and contains a chitin-binding domainEU414751.1L7N6F8
Der f 23KU166910—
Group 24, e.g., Der p 2413Ubiquinol-cytochrome c reductase binding protein-like proteinKP893174A0A0K2GUJ4
Der f 24KC669700M9RZ95
Group 25, e.g., Der f 2534Triosephosphate isomeraseKC305500.1L7UZA7
Group 26, e.g., Der f 2618Myosin alkali light chainKM009996bA0A088SAG5b
Group 27, e.g., Der f 2748Serpin–trypsin inhibitorAIO08851—
Group 28, e.g., Der f 2870Heat shock proteinKC305502L7V065
Group 29, e.g., Der f 2916Peptidyl-prolyl cis-trans isomerase (cyclophilin)AY283280.1A1KXG2
Group 30, e.g., Der f 3016FerritinKC305503L7UZ91
Group 31, e.g., Der f 3115Cofilin, actin binding proteinKM010014A0A088SAY1
Group 32, e.g., Der f 3235Secreted inorganic pyrophosphataseKM009993A0A088SCP3
Group 33, e.g., Der f 3352α-tubulinKM010005A0A088SV41
Group 34, e.g., Der f 3416Enamine/imine deaminaseLC120618A0A1J1DL12
Group 35, e.g., Der f 3514MD-2–related protein homologous with group 2LC175222A0A1W7HBY9
Group 36, e.g., Der p 3642Function unknown; contains a C-terminal C2 domain (pfam00168) associated with signal transductionKY465507A0A291KZD3
Der f 36KY465506A0A291KZC2
Group 37, e.g., Der p 3730Peritrophic-like protein domainMG520330c—

  • EBML, European Molecular Biology Laboratory.

  • ↵a Glycosylated forms of 63-kDa protein predicted by DNA sequence.

  • ↵b Note that GenBank/European Bioinformatics Institute and UniProt incorrectly designate this as a group 30 allergen. Definitively, it is a group 26 allergen as designated by the Allergen Nomenclature Sub-Committee of the World Health Organization and International Union of Immunologic Societies. Please refer to http://www.allergen.org/viewallergen.php?aid=815 for further information.

  • ↵c Accession not yet published.