Metformin pharmacokinetic parameters from pregnant Oct3+/+ and Oct3−/− mice
Data are presented as mean ± S.E. (Cmax) or with 95% confidence intervals in parentheses.
| Oct3+/+ | Oct3−/− | |
|---|---|---|
| Cmax (µg/ml) | 3.31 ± 0.45 | 4.17 ± 0.37 |
| AUC0–480min (μg/ml*min) | 609 (564, 698) | 513 (452, 569)* |
| AUC0–∞ (μg/ml*min) | 661 (616, 753) | 556 (494, 615) |
| CL/F[(ml/min)/kg] | 24.6 (21.5, 26.6) | 29.3 (26.4, 33.2) |
| t1/2, β (min) | 119 (107, 195) | 154 (99.2, 234) |
| Vβ (l/kg) | 4.21 (3.60, 7.11) | 6.51 (4.23, 10.3) |
↵* Significantly different from Oct3+/+ (P < 0.05).