TABLE 2

Reduction in secreted cytokines by C-DIM5

Inflammatory cytokines secreted upon MPTP/IFNγ/TNFα treatment are significantly reduced upon addition of C-DIM5.

Group	Secreted Cytokine Concentration (pg/ml)						TARC
Group	IL2	IL6	IL-12p70	CCL2	MIP-1a	CCL5
Control	—	1.9 ± 0.65^*	-^**	13.2 ± 0.67^**	-^*	5.7 ± 0.52^**	9.6 ± 0.47^*
MPTP/TNF/IFN	3.1 ± 0.24	84.6 ± 1.13	7.4 ± 0.33	750.4 ± 7.58	4.1 ± 1.09	1916 ± 153.55	18.4 ± 0.80
MPTP/TNF/IFN + C-DIM5	2.6 ± 0.15	55.1 ± 2.53^**	2.4 ± 0.27^**	279.5 ± 5.74^**	—^*	111.2 ± 3.08^**	16.6 ± 1.46^*

—, Result lower than limit of detection.
↵* P < 0.01; **P < 0.001 Statistical significance from MPTP/TNF/IFN group (n = 4/group).