Gene ontology (GO) terms overrepresented among expressed genes that correlated with evofosfamide IC50 in cancer cell lines treated under anoxia
Genes with expression levels that were inversely correlated with evofosfamide IC50 values under anoxia (Pearson coefficient ≤ –0.4, which defined 173 genes) were assessed for overrepresentation of GO annotations using Fisher’s exact tests. The resulting P values were adjusted for multiple comparisons (i.e., all possible GO terms) using the Benjamini–Hochberg method. The fold enrichment of each significant (adjusted P value <0.05) GO annotation (i.e., the ratio of the actual to the expected number of genes on the list with the annotation given random sampling) is denoted.
| GO Term | Fold Enrichment | Adjusted P Value |
|---|---|---|
| GO0005743: Mitochondrial inner membrane | 5.29 | <10−7 |
| GO0005759: Mitochondrial matrix | 5.10 | 10−4 |
| GO0005840: Ribosome | 6.69 | 10−3 |
| GO0044822: Poly(A) RNA binding | 2.34 | 0.002 |
| GO0005739: Mitochondrion | 2.45 | 0.009 |
| GO0046872: Metal ion binding | 1.93 | 0.009 |
| GO0070125: Mitochondrial translational elongation | 2.39 | 0.02 |
| GO0070126: Mitochondrial translational termination | 11.58 | 0.03 |