Phosphodiesterase with Affinity to cAMP and Their Inhibitors
| PDE Inhibitors | Target | Substrate | Reference |
|---|---|---|---|
| Rolipram | PDE4 | cAMP | (Kim et al., 2017) |
| Apremilast | PDE4 | cAMP | (Schett et al., 2010) |
| Crisaborole | PDE4 | cAMP | (Paller et al., 2016) |
| Roflumilast | PDE4 | cAMP | (Baye, 2012) |
| Cilomilast | PDE4 | cAMP | (Compton et al., 2001) |
| Theophylline | NonselectivePDE4 | cAMP | (Barnes, 2013) |
| Dipyridamole | NonselectivePDE6, PDE8 | cAMP | (Gillespie and Beavo, 1989) |
| Zaprinast | NonselectivePDE6 | cAMP | (Zhang et al., 2005) |
PDE, phosphodiesterase.