Ca2+-activated tension parameters for skinned fiber bundles of adult TG-ssTnI mice and NTG controls treated with 0.3 µM Mava
Data are presented as mean ± S.D. Two-way ANOVA test followed by a Tukey’s multiple comparison post hoc test.
| Skinned Fibers | Treatment | Max Tension(mN/mm2) | pCa50 | Hill Slope |
|---|---|---|---|---|
| NTG adult (n = 5) | Control | 35.38 ± 4.93 | 5.68 ± 0.08 | 4.05 ± 0.86 |
| NTG adult (n = 5) | Mava 0.3 µM | 19.89 ± 3.92a | 5.55 ± 0.07 | 4.96 ± 0.95 |
| TG-ssTnI adult (n = 6) | Control | 29.05.05 ± 4.27b | 5.88 ± 0.13c,d | 3.24 ± 0.68e |
| TG-ssTnI adult (n = 6) | Mava 0.3 µM | 14.19 ± 4.41f,g | 5.73 ± 0.12 | 3.46 ± 0.96h |
aP = 0.0001, 95% CI of diff. [7.65 to 23.34] when compared with NTG adult control
bP = 0.0139, 95% CI of diff. [−16.68 to −1.65] when compared with NTG 0.3 µM Mava
eP = 0.029, 95% CI of diff. [−0.38 to −0.02] when compared with NTG adult control
fP = 0.0005, 95% CI of diff. [−0.51 to −0.14] when compared with NTG 0.3 µM Mava
gP = 0.0201, 95% CI of diff. [−3.19 to −0.23] when compared with NTG adult 0.3µM Mava
cP < 0.0001, 95% CI of diff. [13.68 to 28.71] when compared with NTG adult control
dP < 0.0001, 95% CI of dif. [7.70 to 22.03] when compared with TG-ssTnI adult control
hP = 0.0465, 95% CI of diff. [−2.98 to −0.02] when compared with NTG adult 0.3 µM Mava