Research Articles
Urinary Metabolic Profiles for Choosing Test Animals for Chronic Toxicity Studies: Application to Naproxen

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Abstract:

Gradient elution ion-exchange chromatography was employed to determine urinary metabolic profiles of naproxen in test animals and humans. Retention molarities were found to be very reproducible, and the quantitation and column recovery were good. The profiles add another dimension to the basic information required to pick the most appropriate test animal for the chronic toxicological evaluation of a new drug. Based on the profiles, the mini pig and rat appeared to be the animals of choice for the chronic toxicological evaluation of naproxen.

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