Regular ArticlePurification of a Phenobarbital-Inducible UDP-Glucuronosyltransferase Isoform from Dog Liver Which Catalyzes Morphine and Testosterone Glucuronidation
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Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT
2020, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Animal experiments in this study were approved by the institutional Animal Care and Experiment Committee of Kyushu University (application approval numbers: A26–026, A28-024, and A30-104) and they followed the ARRIVE guidelines. FVB mice (seven-week-old, male) were purchased from CLEA Japan (Tokyo, Japan) and liver microsomes were prepared by differential centrifugation described elsewhere [16]. MLM was used as a positive control in immunoblotting and Ugt assays.
Possible drug-drug interaction in dogs and cats resulted from alteration in drug metabolism: A mini review
2015, Journal of Advanced ResearchCitation Excerpt :Phenobarbital also induces UDP-glucuronosyltransferase in dogs. Oguri et al. demonstrated 3-fold increase in morphine glucuronidation in hepatic microsomes obtained from dogs treated with phenobarbital [21]. As NSAIDs were mainly eliminated from the body by biotransformation via glucuronidation, we, therefore, examined the effects of the phenobarbital treatment (5 mg/kg/day p.o., bid) on pharmacokinetics of carprofen after intravenous and oral administration in dogs.
Activation of morphine glucuronidation by fatty acyl-CoAs and its plasticity: A comparative study in humans and rodents including chimeric mice carrying human liver
2010, Drug Metabolism and PharmacokineticsLong-lasting enhancement of CYP activity after discontinuation of repeated administration of phenobarbital in dogs
2009, Research in Veterinary ScienceTissue-specific regulation of canine intestinal and hepatic phenol and morphine UDP-glucuronosyltransferases by β-naphthoflavone in comparison with humans
2002, Biochemical PharmacologyCitation Excerpt :Both M3G and M6G formation were clearly detectable in dog liver microsomes (Fig. 4). UGT activities toward morphine were not induced by BNF but marginally enhanced in phenobarbital-treated dog liver microsomes (ca. 1.5-fold), in agreement with [19]. Hepatic UGT activity toward 4-methylumbelliferone was not enhanced by the two inducers, but UGT activity toward 4-hydroxybiphenyl was moderately enhanced by both BNF and phenobarbital (P=0.056).
Formation of a Structurally Novel, Serial Diglucuronide of 4-Hydroxybiphenyl by Further Glucuronidation of a Monoglucuronide in Dog Liver Microsomes
2002, Drug Metabolism and Pharmacokinetics