Regular ArticleThe Schizosaccharomyces pombe pde1/cgs2 Gene Encodes a Cyclic AMP Phosphodiesterase
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Atf1-Pcr1-M26 complex links stress-activated MAPK and cAMP-dependent protein kinase pathways via chromatin remodeling of cgs2
2004, Journal of Biological ChemistryCitation Excerpt :Second, there should be some indication (experimental or hypothetical) that the genes have a role in sexual differentiation in response to nutritional stress conditions. The cgs2+ (pde1+) gene was selected as a good candidate for further study: It was identified in a screen for mutants unable to undergo normal meiosis (26) and independently in a screen for S. pombe cDNA clones that could suppress the heat-shock-sensitive phenotypes of iraΔ mutants of Saccharomyces cerevisiae (27, 28). Cgs2 protein is a phosphodiesterase that has a major role in regulating the single cAMP-dependent protein kinase (PKA) pathway of fission yeast (9, 26, 28, 29).
The RHEB-mTOR axis regulates expression of Tf2 transposons in fission yeast
2018, Journal of Cell ScienceBiological roles of cAMP: Variations on a theme in the different kingdoms of life
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