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Cloning, Expression and Characterization of Human α Adrenergic Receptors α1a, α1b and α1c

https://doi.org/10.1006/bbrc.1994.1845Get rights and content

Abstract

The three human α adrenergic receptor subtypes, α1a, α1b, and α1c, have been cloned, expressed in COS-7 cells, and characterized pharmacologically. Competition binding studies of several adrenergic ligands with the three human receptor subtypes reveals a distinct pharmacological profile for each receptor subtype. RNase protection analysis demonsrates that the three receptor subtypes have different patterns of distribution in human tissue. The availability of the three human α1 receptor subtypes will facilitate the development of subtype-selective α1 antagonists for a variety of therapeutic indications.

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