Biochemical and Biophysical Research Communications
Regular ArticlePhosphorylation and Activation of Mitogen-Activated Protein Kinase by Kainic Acid-Induced Seizure in Rat Hippocampus
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The protective effect of the endocannabinoid system in neurotoxin-induced damage to hippocampal neurons: a focus on light and electron microscopy
2023, Neurobiology and Physiology of the Endocannabinoid SystemContrasting features of ERK1/2 activity and synapsin i phosphorylation at the ERK1/2-dependent site in the rat brain in status epilepticus induced by kainic acid in vivo
2015, Brain ResearchCitation Excerpt :A number of studies using cultured neurons have shown that ERK1/2 is activated in response to excitatory glutamatergic stimulation and following Ca2+-influx into neurons (Bading and Greenberg, 1991; Fiore et al., 1993; Kurino et al., 1995; Murphy et al., 1994). Robust ERK1/2 activation has also been observed in various types of seizure models, implicating a close relationship between neuronal excitation and ERK1/2 activation in vivo (Baraban et al., 1993; Gass et al., 1993; Kim et al., 1994; Murray et al., 1998; Merlo et al., 2004; Jeon et al., 2000; Lugo et al., 2008; de Lemos et al., 2010; Yamagata et al., 2002, 2013). Elucidating signaling cascades that involve ERK1/2 has been a focus of attention, especially in the context of synaptic plasticity and learning and memory, and a number of direct targets of ERK1/2 have been documented (Sweatt, 2004; Thomas and Huganir, 2004).
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