Biochemical and Biophysical Research Communications
Regular ArticleThe Tyrosine Kinase Inhibitor, Genistein, Prevents α-Adrenergic-Induced Cardiac Muscle Cell Hypertrophy by Inhibiting Activation of the Ras-MAP Kinase Signaling Pathway
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The Pathophysiology of Cardiac Hypertrophy and Heart Failure
2014, Cellular and Molecular Pathobiology of Cardiovascular DiseasePharmacology of Polyphenols in Cardiac Remodeling: Potential Biological Mechanisms
2013, Polyphenols in Human Health and DiseaseRegulation of telomerase activity by apparently opposing elements
2010, Ageing Research ReviewsCitation Excerpt :Genistein, a natural isoflavone similar to estrogen and present in soybean, has been shown to inhibit a number of cancers, including prostate cancer (Alhasan et al., 2001; El Touny and Banerjee, 2009; Majid et al., 2008). Genistein inhibits epidermal growth factor receptor tyrosine kinase (Akiyama et al., 1987; Markovits et al., 1989; Thorburn and Thorburn, 1994), inhibits DNA topoisomerase II in Chinese hamster lung cells (Markovits et al., 1989) and induces p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells (Majid et al., 2008; Rao et al., 2004). In addition, genistein has been shown to inhibit telomerase in prostate cancer (Chau et al., 2007; Jagadeesh et al., 2006; Ouchi et al., 2005) and breast cancer (Li et al., 2009).
S1P<inf>1</inf> receptor localization confers selectivity for G <inf>i</inf>-mediated cAMP and contractile responses
2008, Journal of Biological ChemistryCitation Excerpt :One possible explanation is that different Gi subunits mediate these responses. Inhibition of the major isoforms of adenylyl cyclase in the heart (ACV/VI) is known to be mediated by the α subunit of Gi (47), whereas activation of MAP kinases and Akt is thought to occur through β/γ subunits (32, 48–51). One might speculate that β/γ subunits released when Gi is activated through the caveolar S1P1 receptor are unable to access the signaling molecules (e.g. phosphatidylinositol 3-kinase and Ras) that ultimately activate Akt and ERK.
Wortmannin inhibits the myofilament Ca<sup>2+</sup> sensitization induced by endothelin-1
2005, European Journal of PharmacologyThe effect of insulin-like growth factor-I on production of vascular endothelial growth factor by amnion-derived (WISH) cells
2004, Growth Hormone and IGF Research