Biochemical and Biophysical Research Communications
Regular ArticleNitric Oxide Inhibits Migration of Cultured Endothelial Cells
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Local pharmacological induction of angiogenesis: Drugs for cells and cells as drugs
2019, Advanced Drug Delivery ReviewsCitation Excerpt :Upregulation of eNOS and consequent release of NO in EC is heavily dependent on different growth factors such as VEGF, heparin binding EGF (HB-EGF) and TGF-β1, and on PI3K signalling and integrin α5β3 activity [185–189]. However, there is controversy regarding the role of NO in angiogenesis, as exogenous supplementation of HUVEC cultures with organic NO donors, presented decreased cell migration [190]. Furthermore, there is in vivo data available that appears to substantiate the anti-angiogenic effect of NO, since it has been demonstrated that the use of NO donors in a CAM model led to decreased collagen synthesis and vascular density [182,191].
Glycosylation as new pharmacological strategies for diseases associated with excessive angiogenesis
2018, Pharmacology and TherapeuticsRosuvastatin promotes angiogenesis and reverses isoproterenol-induced acute myocardial infarction in rats: Role of iNOS and VEGF
2012, European Journal of PharmacologyCitation Excerpt :There is a controversy regarding the role of NO in angiogenesis. It has been reported that NO inhibited migration of cultured endothelial cells in vitro, an important step in angiogenesis (Lau and Ma, 1996). Similarly, NO donors were reported to inhibit angiogenesis in the model of chick chorioallantoic membrane as well as tube formation in the matrigel tube formation assay (Pipili-Synetos et al., 1993, 1994).
Role of simvastatin and/or antioxidant vitamins in therapeutic angiogenesis in experimental diabetic hindlimb ischemia: Effects on capillary density, angiogenesis markers, and oxidative stress
2012, European Journal of PharmacologyCitation Excerpt :The regulation of capillary growth by nitric oxide is complex due to both angiogenic and antiangiogenic effects of nitric oxide (Lau and Ma, 1996; RayChaudhury et al., 1996). Moreover, the role of nitric oxide synthase isoforms in angiogenesis is controversial (Lau and Ma, 1996). HO-1 has been suggested to have a role in angiogenesis in vitro, however, the relevance of this in vivo remains unknown.
Sonic Hedgehog on Microparticles and Neovascularization
2012, Vitamins and HormonesCitation Excerpt :Capillary EC growth and differentiation is linked to cyclic GMP (cGMP) generation, suggesting the existence of an autocrine/paracrine loop in NO effect (Ziche and Morbidelli, 2000). The regulation of capillary growth by NO is complex because both angiogenic and angiostatic effects of NO have been demonstrated (Lau and Ma, 1996; Murohara et al., 1998; RayChaudhury et al., 1996; Ziche et al., 1994). NO generate upon constitutive eNOS activation can stimulate soluble guanylyl cyclase (sGC) in an autocrine manner in ECs or diffuse outside.
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Corresponding Author: Ying-Tung, Lau. FAX:886-3-3283031.