Biochemical and Biophysical Research Communications
Regular ArticleThe Dendritic Translocation of Translin Protein in the Form of BC1 RNA Protein Particles in Developing Rat Hippocampal Neurons in Primary Culture
References (27)
- et al.
J. Biol. Chem.
(1991) - et al.
Biochem. Biophys. Res. Commun.
(1998) - et al.
Mech. Aging Dev.
(1987) - et al.
Neurosci. Lett.
(1996) - et al.
Biochem. Biophys. Res. Commun.
(1998) - et al.
J. Biol. Chem.
(1992) - et al.
FEBS Lett.
(1997) - et al.
Biochem. Biophys. Res. Commun.
(1997) - et al.
Proc. Natl. Acad. Sci. U.S.A.
(1982) - et al.
J. Neurochem.
(1986)
Proc. Natl. Acad. Sci. U.S.A.
Proc. Natl. Acad. Sci. U.S.A.
Mol. Cell. Biol.
Cited by (47)
Roles of lncRNAs in brain development and pathogenesis: Emerging therapeutic opportunities
2023, Molecular TherapyFar from the nuclear crowd: Cytoplasmic lncRNA and their implications in synaptic plasticity and memory
2021, Neurobiology of Learning and MemoryCitation Excerpt :Similarly, the immunoprecipitation of KIF5 has identified synaptic transcriptomes that are transported to neuronal dendrites in Aplysia neurons (Puthanveettil et al., 2013). Consistent with these reports, dendritic transport of BC1 lncRNA occurs in association with dendritic RBPs, such as Staufen1/2, Translin and FMRP (Kobayashi et al., 1998; Mallardo et al., 2003; Zalfa et al., 2003). These observations suggest that a mapping of lncRNA-RBP interaction is imperative to bolster our understanding of targeted trafficking of lncRNAs to translationally competent compartments.
Phospholipase Cβ connects G protein signaling with RNA interference
2016, Advances in Biological RegulationCitation Excerpt :TRAX and translin are present at high levels in neurons. Mutagenesis studies show that these proteins play key roles in function and development in cultured cells of neuronal linage and in the neural system of whole animals, although the underlying basis is unknown (Finkenstadt et al., 2000; Kobayashi et al., 1998; Stein et al., 2006; Wu et al., 1997). The ability of TRAX in the context of C3PO to regulate these processes through generation of specific miRs is now being investigated.
Non-coding mechanisms of local mRNA translation in neuronal dendrites
2015, European Journal of Cell BiologyCitation Excerpt :BC1 contains a specific cis-acting element that is required for its transport to dendritic processes in an activity-dependent manner (Muslimov et al., 1998, 1997). Though the transport RNP that mediates the dendritic sorting of BC1 is not fully characterized, it likely contains translin and staufen proteins based on biochemical fractionation experiments (Kobayashi et al., 1998; Mallardo et al., 2003). BC1 was implicated in the regulation of translation in dendrites (Wang et al., 2002), evidently in association with the fragile X syndrome protein FMRP (Zalfa et al., 2003), though this finding remains controversial (Iacoangeli et al., 2008; Wang et al., 2005).
Dendritic protein synthesis in the normal and diseased brain
2013, NeuroscienceCitation Excerpt :Indeed, translin has been shown to regulate dendritic targeting of BDNF mRNA through a sequence within the coding region of BDNF (Chiaruttini et al., 2009). Translin is associated with regulation of local protein synthesis as well as learning and memory (Kobayashi et al., 1998; Muramatsu et al., 1998; Finkenstadt et al., 2000; Li et al., 2008), and translin knockout mice have altered spatial memory, fear learning, and anxiety behaviors (Stein et al., 2006). These data suggest that altered local BDNF production could contribute to synaptic dysfunction in patients and warrant further investigations into the connection between altered BDNF synthesis at synapses and psychiatric disorders.
The Translin/Trax RNA binding complex: Clues to function in the nervous system
2008, Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
- 1
To whom correspondence should be addressed. Fax: +81 47 4655867.