Biochemical and Biophysical Research Communications
Regular ArticleAttachment of C-Terminus of SDF-1 Enhances the Biological Activity of Its N-Terminal Peptide
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2012, Trends in Cardiovascular MedicineCitation Excerpt :The inflammatory environment of infarcted myocardium is particularly hostile for any type of transplanted cell, leading to a typical 90% cell death within 1 week (Segers and Lee 2008). It is our belief that smaller engineered analogs of SDF may provide translational advantages, including enhanced stability and function, ease of synthesis, lower cost, and, most important, the potential for modulated delivery via engineered biomaterials (Baumann et al. 2012, Luo et al. 1999, Prokoph et al. 2012, Segers et al. 2007). With that in mind, we set out to design and engineer a minimized, highly efficient polypeptide analog of the SDF molecule using computational molecular modeling and design.
Engineering and screening the N-terminus of chemokines for drug discovery
2011, Biochemical PharmacologyCitation Excerpt :Addition of special moieties could stabilise the structure of the peptide and enhance its affinity for the receptor. Nowadays, the only extension described corresponds to the attachment of the C-terminal part of CXCL12a, CXCL12a(56–67) to its N-terminal peptide CXCL12a(5–14) via a glycine linker, a modification described for the first time in 1999 by Luo et al. [192,193]. Although the C-terminus of CXCL12a had no activity and did not bind the receptor, linkage to CXCL12a(5–14) dramatically increased chemotaxis and calcium signalling activities of the peptide.
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