Regular ArticlePurification, Identification, and Characterization of an Osmotic Response Element Binding Protein☆,☆☆
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Cited by (119)
TNF-α promotes nuclear enrichment of the transcription factor TonEBP/NFAT5 to selectively control inflammatory but not osmoregulatory responses in nucleus pulposus cells
2017, Journal of Biological ChemistryCitation Excerpt :In NP cells, TNF-α treatment promoted nuclear localization of TonEBP without affecting mRNA or total protein levels. This is in contrast to osmotic activation of TonEBP, which includes a rapid mRNA induction, increase in total protein abundance, and nuclear translocation (45–47). Moreover, our result is in partial agreement with a previous report showing that TNF-α and IL-1β (25) can enhance both the total and nuclear fraction of TonEBP in other cell types.
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This work was supported by Research Grant Council Grant HKU7278/97M.
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Abbreviations used: AR, aldose reductase; BGT1, betaine/γ-aminobutyric acid transporter; SMIT, Na+-dependent myo-inositol transporter; OREs, osmotic response elements; NFAT, nuclear factor of activated T cells; TonE, tonicity-responsive enhancer; OREBP, osmotic response element binding protein
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