Regular ArticleEvidence for Cadmium Uptake through Nramp2: Metal Speciation Studies with Caco-2 Cells
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Molecular Mechanism of Nramp-Family Transition Metal Transport
2021, Journal of Molecular BiologyThe transfer of trace metals in the soil-plant-arthropod system
2021, Science of the Total EnvironmentCitation Excerpt :DMT 1 actively transports Ni (Illing et al., 2007) and has been implicated in Ni uptake in rat jejunal segments (Muller-Fassbender et al., 2003). However, this raises an issue for some insects with a high midgut pH, such as the Lepidoptera and those that feed on hemicellulases (Chapman, 1998; Gullan and Cranston, 2005), as DMT 1 is a Me2+/H+ symporter that requires an extra- to inter-cellular proton gradient for transport (Bannon et al., 2003; Elisma and Jumarie, 2001; Gunshin et al., 1997; Okubo et al., 2003); transport by DMT 1 appears to be negligible at pH < 7 (Elisma and Jumarie, 2001; Okubo et al., 2003). Typical midgut pH values for arthropods tend towards pH 6.0–6.5, which should be sufficient for DMT 1/Mlv transport (Okubo et al., 2003; Martínez-Barnetche et al., 2007).
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2017, ChemosphereCitation Excerpt :However, significantly lower levels and bioconcentartion ratios were measured for Cd in the presence of 200 ppm Fe compared to 40 ppm Fe, suggesting that high concentrations of Fe could interfere with the accumulation processes of Cd. The mammalian proton-dependent divalent cation transporter NRAMP2 (DMT1/DCT1) has a broad selectivity (Gunshin et al., 1997), and competition between Fe and Cd for NRAMP2-mediated transport in intestinal cells has been demonstrated (Elisma and Jumarie, 2001). Malvolio (Mvl), the Drosophila melanogaster homologue of Nramp1/2, is expressed in the larva and adult alimentary canal of drosophila (Rodrigues et al., 1995; Folwell et al., 2006).
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