Biochemical and Biophysical Research Communications
Regular ArticleERK Pathway Positively Regulates the Expression of Sprouty Genes☆
References (23)
- et al.
Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways
Cell
(1998) - et al.
Cloning and expression pattern of a mouse homologue of Drosophila sprouty in the mouse embryo
Mech. Dev.
(1999) - et al.
Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis
Curr. Biol.
(1999) - et al.
Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis
Mech. Dev.
(2001) - et al.
Evidence for direct interaction between Sprouty and Cbl
J. Biol. Chem.
(2001) - et al.
Inhibition of angiogenesis by a mouse sprouty protein
J. Biol. Chem.
(2001) - et al.
Human SPRY2 inhibits FGF2 signalling by a secreted factor
Mech. Dev.
(2000) - et al.
Identification of a novel inhibitor of mitogen-activated protein kinase kinase
J. Biol. Chem.
(1998) - et al.
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
J. Biol. Chem.
(1994) - et al.
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
FEBS Lett.
(1995)
Sprouty, an intracellular inhibitor of Ras signaling
Cell
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Spatial signal repression as an additional role of Sprouty2 protein variants
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2018, Progress in Brain ResearchQuantitative proteomics reveals fundamental regulatory differences in oncogenic hras and isocitrate dehydrogenase (IDH1) driven astrocytoma
2017, Molecular and Cellular ProteomicsCitation Excerpt :In addition to perturbed phosphorylation we found multiple changes at the protein abundance level that are consistent with activation of the MAPK pathway. For example, Sprouty protein 4 (SPRY4), whose expression is induced by the MAPK pathway (43, 44), showed a 10-fold upregulation at the protein level. We also found that several key members of the PI3K pathway showed regulation at the phosphorylation level, including AKT1S1, RPTOR, and RICTOR (Fig. 4A and 4B).
Sprouty2 protein regulates Hypoxia-inducible Factor-α (HIFα) protein levels and transcription of HIFα-responsive genes
2016, Journal of Biological ChemistryThe increased Sprouty4 expression in response to serum is transcriptionally controlled by Specific protein 1
2015, International Journal of Biochemistry and Cell BiologyCitation Excerpt :As murine Spry proteins are primarily detected at their place of action, a negative feedback loop is postulated (Chambers and Mason, 2000; Klein et al., 2006; Minowada et al., 1999). Accordingly, Spry protein expression is induced by growth factors as a consequence of mitogen-activated protein kinase (MAPK) activation (Gross et al., 2001; Ozaki et al., 2001). In addition, their expression can be influenced by calcium release (Abe and Naski, 2004) and hypoxia (Haigl et al., 2010).
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Abbreviations used: MAP kinase, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinase; MEK, MAP kinase/ERK kinase; PI3-kinase, phosphatidylinositol-3-kinase; FGF, fibroblast growth factor; EGF, epidermal growth factor; PDGF, platelet-derived growth factor; RTK, receptor tyrosine kinase; PMA, phorbol 12-myristate 13-acetate; PAGE, polyacrylamide gel electrophoresis.
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