Biochemical and Biophysical Research Communications
Regular ArticleInhibition of Ceramide Production Reverses TNF-Induced Insulin Resistance
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Silkworm Extract Ameliorates Type 2 Diabetes Mellitus and Protects Pancreatic β-cell Functions in Rats
2020, Digital Chinese MedicineCitation Excerpt :Results showed that these anti-diabetic effects may be mediated by alleviating pancreatic inflammation and oxidative stress, preserving and repairing damaged islet cells, and reducing islet dysfunction. Previous studies have demonstrated that inflammatory factor-mediated inflammation plays a critical role in diabetes development [14-16]. TNF-α is mainly secreted by macrophages and adipocytes in adipose tissues, sustaining mildly elevated levels under pathological conditions [14].
Tumor Necrosis Factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (CGK)-Iα causes insulin resistance in 3T3-L1 adipocytes
2015, Journal of Biological ChemistryCitation Excerpt :TNF-α is shown to activate various kinases, including Jun kinases, mitogen-activated protein kinases, and protein kinase Cs, to phosphorylate IRS-1, resulting in repression of its tyrosine phosphorylation in response to insulin and insulin bioactivities (25, 50, 51). TNF-α also increases lipids, such as diacylglycerols, ceramides, and ganglioside GM3, resulting in inhibition of insulin-dependent IR activation and its proximal signaling (52–55). In addition, knockdown of cGK-Iα could only restore GKAP42 protein level and not IRS-1 protein level, indicating that a degradation system other than cGK-Iα was induced by TNF-α treatment.
Glycosphingolipids and insulin resistance
2009, Progress in Lipid ResearchCitation Excerpt :A report by Grigsby and Dobrowsky suggests that exposing 3T3-adipocytes to TNFα increases caveolar ceramide concentration and impairs IR function. Prevention of ceramide accumulation using Z-VAD-FMK, a caspase inhibitor, restored IR and IRS-1 phosphorylation [78]. Kabayama et al. reported the effect of prolonged TNFα exposure on IR localization in 3T3-adipocytes [79].
TNF-α and adipocyte biology
2008, FEBS LettersTumor necrosis factor (TNF) interferes with insulin signaling through the p55 TNF receptor death domain
2005, Biochemical and Biophysical Research Communications
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