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Association between Oxidative Stress and Bone Mineral Density

https://doi.org/10.1006/bbrc.2001.5747Get rights and content

Abstract

Free radicals have been shown to be involved in bone resorption in vitro and in rodents. We studied the effect of oxidative stress on bone mineral density (BMD) in 48 women and 53 men from a population-based study. The levels of 8-iso-PGF (a major F2-isoprostane and a biomarker of oxidative stress) and a control, 15-keto-dihydro-PGF (a biomarker of inflammatory response), were measured in urinary samples and their association with BMD and quantitative ultrasound (QUS) measurements were examined. In multivariate linear regression analyses, 8-iso-PGF levels were negatively associated with both BMD and QUS. In contrast, no association was found for 15-keto-dihydro-PGF. Our findings establish a biochemical link between increased oxidative stress and reduced bone density and provide a rational for further studies investigating the role of pro- and antioxidants in osteoporosis.

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    Abbreviations used: COX, cyclooxygenase; PG, prostaglandin; 8-iso-PGF, 8-iso-prostaglandin F; 15-keto-dihydro-PGF, 15-keto-13,14-dihydro-prostaglandin F; PGF, prostaglandin F; CCl4, carbon tetrachloride; BMD, bone mineral density; QUS, quantitative ultrasound.

    1

    To whom correspondence should be addressed at Sections of Geriatrics and Clinical Nutrition Research, Uppsala University, Box 609, S-751 25 Uppsala, Sweden. Fax: (46)-18-6117976. E-mail. [email protected].

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