Elsevier

Developmental Biology

Volume 243, Issue 2, 15 March 2002, Pages 209-214
Developmental Biology

Review
Morpholino Oligos: Making Sense of Antisense?

https://doi.org/10.1006/dbio.2001.0565Get rights and content
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Abstract

Since morpholino oligos were first introduced as a means to inhibit gene function in embryos, in the Spring of 2000, they have been tested in a range of model organisms, including sea urchin, ascidian, zebrafish, frog, chick, and mouse. This review surveys the results of these studies and examines the successes and limitations of the approach for targeting maternal and zygotic gene function. The evidence so far suggests that, with careful controls, morpholinos provide a relatively simple and rapid method to study gene function.

Keywords

antisense
morpholino
embryo

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