Regular ArticleTelomere Length Dynamics in Telomerase-Positive Immortal Human Cell Populations
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Processive and Distributive Extension of Human Telomeres by Telomerase under Homeostatic and Nonequilibrium Conditions
2011, Molecular CellCitation Excerpt :The generality of this observation was examined in HeLa cervical carcinoma cells. Only ∼70% of HeLa cells express telomerase at any given time (Bryan et al., 1998), and 70% of telomere ends were extended by telomerase during each cell cycle (Figure 2C, top). As with H1299 cells, inhibition by GRN163L resulted in a decrease in the fraction of extended ends without changing their density (Figure 2C, middle).
Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP
2010, European Journal of PharmacologyIn vivo stoichiometry of shelterin components
2010, Journal of Biological ChemistryCitation Excerpt :The successive subclones are called HeLa1.2, HeLa1.2.11, and HeLa1.3. The telomere lengths of the HeLa clones from the last round of subcloning are shown in supplemental Fig. 1A, which demonstrates the previously noted telomere length heterogeneity of HeLa subclones (41). This latest round of subcloning also yielded HeLa204, a cell line with telomeres in the 6-kb range.
- 1
Current address: Department of Chemistry and Biochemistry, Campus Box 215, HHMI, University of Colorado, Boulder, CO 80309-0215.
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To whom correspondence should be addressed at Children's Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia. Fax: +61-2-9687 2120. E-mail:[email protected].