Regular ArticleSuppressive Actions of Betaxolol on Ionic Currents in Retinal Ganglion Cells May Explain its Neuroprotective Effects
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2011, Progress in Retinal and Eye ResearchApplication of isoproterenol inhibits diabetic-like changes in the rat retina
2010, Experimental Eye ResearchCitation Excerpt :Recent work in non-diabetic rodents demonstrated that a β-adrenergic receptor antagonist produced a significant loss of B-wave amplitude and increased angiogenic growth factors (Jiang and Steinle, 2010). Work in glaucoma has suggested that β-adrenergic receptor antagonists are neuroprotective, however, this is likely due to other effects other than β-adrenergic receptor neurotransmission (Osborne et al., 2005), such as calcium regulation (Hirooka et al., 2000). We did observe some changes in the heart histology; however, no changes in blood pressure or intraocular pressure were noted in the isoproterenol-treated animals.
- f1
Address correspondence to: Steven Barnes, Department of Physiology & Biophysics, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada. E-mail: [email protected]
- f2
Permanent address: Department of Ophthalmology, Kagawa Medical University, 1750-1, Ikenobe, Mikicho, Kagawa, Japan 761-0793.