Regular ArticleEndogenous BDNF Protein Is Increased in Adult Rat Hippocampus after a Kainic Acid Induced Excitotoxic Insult but Exogenous BDNF Is Not Neuroprotective
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Chemogenetic inhibition of TrkB signalling reduces phrenic motor neuron survival and size
2023, Molecular and Cellular NeuroscienceSynapse-specific changes in Arc and BDNF in rat hippocampus following chronic temporal lobe epilepsy
2023, Neuroscience ResearchDexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling
2019, Neurochemistry InternationalCitation Excerpt :BDNF exerts its neuroprotective effect through pro-survival mechanisms, regulating hippocampal synaptic plasticity and neurogenesis (Nagahara and Tuszynski, 2011; Zuccato and Cattaneo, 2009). Here, we observed that a significant increase in BDNF and TrkB levels in the hippocampus 24 h after KA injection, which is consistent with other studies (Gleeson et al., 2010; Rudge et al., 1998; VonDran et al., 2014). Notably dexmedetomidine pretreatment induced an even greater expression in BDNF and TrkB in the hippocampus of KA-treated rats.
Activation of BDNF-TrkB signaling pathway-regulated brain inflammation in pentylenetetrazole-induced seizures in zebrafish
2018, Fish and Shellfish ImmunologyCitation Excerpt :BDNF, a neurotrophin present in large amount in the brain, regulates neuronal survival, growth, differentiation, and synaptic plasticity by activating its specific receptor tropomyosin receptor kinase B (TrkB) signal transduction pathway [17]. Accumulating studies suggested that seizures induce drastic increases in BDNF expression and enhance activation of TrkB in both animal models and humans [18–23]. In turn, BDNF shows effects that facilitate seizures [24–27].