Elsevier

Genomics

Volume 17, Issue 1, July 1993, Pages 106-109
Genomics

Regular Article
Comparative Mapping of the Grpr Locus on the X Chromosomes of Man and Mouse

https://doi.org/10.1006/geno.1993.1290Get rights and content

Abstract

The gastrin-releasing peptide receptor has been previously cloned from both humans and mice. We have mapped the mouse gastrin-releasing peptide receptor (Grpr) locus using a polymorphic CA21 repeat located in the 5′ untranslated region of the gene and a Mus spretus/Mus musculus interspecific backcross. The Grpr locus mapped between the Pdha-1 and Amg loci on the mouse X chromosome. Studies in man indicate that GRPR maps to the Xp21.2-p22.3 region of the human X chromosome and not to the Xp11-q11 interval as previously reported. The assignment of the GRPR locus to the distal Xp region is supported by the comparative map position in the mouse.

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