Regular ArticleGenomic Structure of Human L-Type Ca2+ Channel
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Vascular Ca<inf>V</inf>1.2 channels in diabetes
2022, Current Topics in MembranesCitation Excerpt :CaV1.2 channels are subject to alternative splicing—a molecular biological transcriptional process that generates many variants from a single gene and may be involved in functional CaV1.2 diversity in health and disease (Hu, Liang, & Soong, 2017; Liao & Soong, 2010; Liao et al., 2007; Yang et al., 2000). The human gene for the CaV1.2 channel (cacna1c) has 50 exons, whereas the mouse and rat forms have 49 exons (Cheng et al., 2007; Liao, Yong, Liang, Yue, & Soong, 2005; Soldatov, 1994). At least 20 exons in the human cacna1c gene are possible sites for alternative splicing.
Voltage-Gated Calcium Channels
2018, Cardiac Electrophysiology: From Cell to Bedside: Seventh EditionL-type calcium channel: Clarifying the “oxygen sensing hypothesis”
2017, International Journal of Biochemistry and Cell BiologyCitation Excerpt :Although the three-dimensional high resolution cryo-electron microscopy structure of the skeletal muscle isoform (α1S) was recently identified (Wu et al., 2016), the structure of the remaining isoforms, including the cardiac muscle isoform responsible for mediating excitation-contraction coupling in the heart (α1C) is yet to be fully elucidated. The α1C subunit contains 50 exons and 13 alternative splicing loci (Soldatov, 1994; Tang et al., 2004; Wang et al., 2006). All splice variants (UniProtKB: Q13936-1-37) are approximately 2200 amino acid residues in length, comprised of four transmembrane domains (repeats I–IV), as well as cytoplasmic NH3+ (N) and COOH (C) termini (Fig. 1B).
Neuronal cell-type specific DNA methylation patterns of the Cacna1c gene
2013, International Journal of Developmental Neuroscience