SHORT COMMUNICATIONGenomic Organization, 5′-Flanking Region, and Chromosomal Localization of the HumanRGS3Gene☆
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Cited by (14)
KLF4 is a novel candidate tumor suppressor gene in pancreatic ductal carcinoma
2011, American Journal of PathologyCitation Excerpt :This hypothesis is further supported by similar findings reported in gastric cancer, where the loss of the 9q31 region has been significantly associated with the early stages of the disease.20 A second candidate tumor suppressor gene, RGS3, also maps in this region and has also been suggested as a potential tumor suppressor.38–40 However, we were unable to detect any significant change in RGS3 expression within our series, thus excluding RGS3 as a major candidate tumor suppressor gene in our model.
Profile of RGS expression in single rat atrial myocytes
2001, Biochimica et Biophysica Acta - Gene Structure and ExpressionRegulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis
2000, Journal of Biological ChemistryCitation Excerpt :First, does the N-terminal region regulate the ability of RGS3 to inhibit G protein signaling? Second, what is the difference between these two products of the same RGS3 gene (15), besides their differential tissue distribution (8)? Our coimmunoprecipitation experiments (Fig.1) and signaling studies (Figs. 2 and 3) convincingly demonstrate that there is no difference between RGS3 and RGS3T in the binding to Gαq/11 and the ability to inhibit Gq/11-coupled endothelin signaling, suggesting that the N-terminal domain of RGS3 does not regulate its GAP function toward Gαq/11.
RGS proteins: More than just GAPs for heterotrimeric G proteins
1999, Trends in Cell BiologyGenome-wide genetic associations with IFNγ response to smallpox vaccine
2012, Human Genetics
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Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession No. AF006610.
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