Regular ArticleAssessment of Archived Paraffin-Embedded Cervical Condyloma Tissues for Mycoplasma-Conserved DNA Using Sensitive PCR–ELISA☆
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Cited by (22)
Nucleoside-catabolizing enzymes in mycoplasma-infected tumor cell cultures compromise the cytostatic activity of the anticancer drug gemcitabine
2014, Journal of Biological ChemistryCitation Excerpt :The association of different bacteria (e.g. Helicobacter pylori, Salmonella typhi, Chlamidophyla pneumoniae, Mycoplasma sp., and others) with tumor tissue in cancer patients has been repeatedly reported (12, 13). A variety of studies have shown a higher infection ratio (∼30 to 50%) of human solid tumors by mycoplasmas (mostly by Mycoplasma hyorhinis) compared with healthy or non-malignant diseased tissues (14–23). Such preferential colonization of tumor tissue by prokaryotes may be attributed to: (i) aberrant vascularization, (ii) an increased nutrient availability (due to necrotic tissue) at the tumor site, and/or (iii) tumor-directed bacterial chemotaxis (13).
Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs
2015, FEBS Open BioCitation Excerpt :This was demonstrated for both pyrimidine- and purine-derived antimetabolites including gemcitabine, floxuridine, trifluridine, cladribine, and others [6–10]. There have been several reports that mycoplasmas have been shown to preferentially colonize tumor tissue in patients [11–20]. If this phenomenon can be broadly confirmed and since nucleoside-derived drugs are established cornerstones in the chemotherapy of several cancers [21], the presence of such prokaryotes in the tumor microenvironment may be a confounding factor for the efficiency of anticancer nucleoside analogues and of importance for optimization of nucleoside-based cancer treatment [22,23].
Inhibition of pyrimidine and purine nucleoside phosphorylases by a 3,5-dichlorobenzoyl-substituted 2-deoxy-d-ribose-1-phosphate derivative
2012, Biochemical PharmacologyCitation Excerpt :Due to the nature of these drugs they may be subject to enzymatic inactivation (e.g. deamination, dephosphorylation or phosphorolysis) by enzymes involved in nucleo(s)(t)ide catabolism. Several studies show that the expression of NPs is upregulated in tumor cells [10–12] and bacterial NPs may be abundantly present in the tumor microenvironment due to the preferential colonisation of malignant tissues by mycoplasmas [31–37]. Also immunocompromised patients (e.g. patients suffering from AIDS) are known to be prone to mycoplasma infections [38,39].
The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2′-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes
2011, Biochemical PharmacologyCitation Excerpt :Pehlivan et al. found 22% of small cell lung cancer tissue samples and >80% kidney tissue samples of patients suffering renal cell carcinoma to be infected with mycoplasmas compared to 5% and 14%, respectively, in control tissue samples [16,17]. Chan et al. reported a 59% mycoplasma infection rate in ovarian cancer tissues [18] and other studies also reported a high infection rate in gastric [19,20] and cervical condyloma tissues [21]. Due to their reduced set of genes, mycoplasmas lack the pathway for de novo pyrimidine and purine synthesis and therefore express a wide array of salvage nucleo(s)(t)ide-metabolizing enzymes, such as thymidine phosphorylase (TP), deoxycytidine deaminase, etc. [22–25].
The cytostatic activity of pyrimidine nucleosides is strongly modulated by Mycoplasma hyorhinis infection: Implications for cancer therapy
2008, Biochemical PharmacologyCitation Excerpt :A possible association between mycoplasmas and leukaemia has already been suggested in the 1960s [22,23]. More recently, mycoplasmas were detected in tissues of ovarian and cervical cancer, by using sensitive PCR-ELISAs [24,25]. In addition, Mycoplasma penetrans was found to be associated with Kaposi's sarcoma [26].
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Innis, M, AGelfand, D, HSninsky, J, JWhite, T, J
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