Regular ArticleCellular Glutathione Content, in Vitro Chemoresponse, and the Effect of BSO Modulation in Samples Derived from Patients with Advanced Ovarian Cancer
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Computational determination of binding structures and free energies of glucose 6-phosphate dehydrogenase with novel steroid inhibitors
2014, Journal of Molecular Graphics and ModellingCitation Excerpt :In normal cells, the expression of G6PD enzyme is tightly controlled [1]. However, G6PD is overexpressed in many tumors, resulting in a remarkable increase of the G6PD activity in a variety of swollen tumor tissues, including bladder cancer [2], renal cell carcinoma [3], ovarian cancer [4], fiber meat tumor [5], breast cancer [6], endometrial cancer [7], cervical cancer [8], prostate cancer [9,10], and lung cancer [11]. In contrast, tumor cells with low G6PD activity grow more slowly and exhibit enhanced apoptosis [12,13].
Utilization of 6-(methylsulfinyl)hexyl isothiocyanate for sensitization of tumor cells to antitumor agents in combination therapies
2013, Biochemical PharmacologyCitation Excerpt :Our previous study revealed that downregulation of GSH was an important factor for selective toxicity toward CNS-derived tumor cells [33], suggesting that targeting of the key enzyme for GSH homeostasis, namely GCL, with highly selective inhibitors could be used to control the development and progression of cancer. In fact, upregulation of GCLC mRNA expression and GCL activity has frequently been observed in cells derived from human tumors that are resistant to chemotherapeutic agents [34–36], and elevated GSH levels have been implicated in cellular resistance to irradiation and antitumor drugs, such as alkylating agents, platinum compounds, topoisomerase inhibitors, and taxanes [37–40]. It has been reported that drug resistance in tumors can be overcome by administration of the GCL inhibitor l-buthionine-S,R-sulfoximine (BSO) [41–43], which subsequently downregulates GSH and sensitizes the tumor cells to radiation treatment and chemotherapy.
Antiproliferative action of menadione and 1,25(OH)<inf>2</inf>D<inf>3</inf> on breast cancer cells
2009, Journal of Steroid Biochemistry and Molecular BiologyGlutathione-S-transferase P1 isoenzyme polymorphisms, platinum-based chemotherapy, and non-small cell lung cancer
2006, Journal of Thoracic OncologyAspirin inhibits NF-κB activation in a glycolysis-depleted lung epithelial cell line
2005, European Journal of Pharmacology
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