Journal of Molecular Biology
Regular articleThe Involvement of Two Distinct Regions of 23 S Ribosomal RNA in tRNA Selection
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Identification of potential allosteric communication pathways between functional sites of the bacterial ribosome by graph and elastic network models
2017, Biochimica et Biophysica Acta - General SubjectsIntersubunit Bridges of the Bacterial Ribosome
2016, Journal of Molecular BiologyThe presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease
2015, MitochondrionCitation Excerpt :Such synergy could occur if the structural distortion of the PTC, imposed by the 1423C > G (m.3093C > G) mutation (Fig. 2F), effectively amplified the defect introduced by the tRNA alteration. Despite the long distance separating the PTC from the wobble position of tRNA, such an idea would not be too surprising, as it has been amply demonstrated that mutations affecting the structure of the PTC of the LSU can effectively alter the fidelity of decoding in the SSU (Thompson et al., 2001b; O'Connor and Dahlberg, 1995; O'Connor and Dahlberg, 1993). In summary, our present and previous results (Smith et al., 2014), unequivocally expand the number of mt-rRNA mutations associated with human disease and/or ageing that are capable of severely compromising mitoribosomal function.
Modulation of conformational changes in helix 69 mutants by pseudouridine modifications
2015, Biophysical ChemistryCitation Excerpt :Long-range effects of the U/Ψ1917C mutation on the stem-region structure, which are independent of the Ψ modifications, suggest stem-loop crosstalk [19,41]. Mutations at key loop residues, such as 1917, involved in mediating this crosstalk, may also be responsible for monitoring interactions with the P-site tRNA and other translational factors, e.g., A-site tRNA or release factors (RFs), in complete ribosomes [27–29,42], and therefore responsible for lethality in E. coli. A change in stability of an RNA molecule may be correlated to either a structural adaptation or altered conformational flexibility, although not all conformational changes lead to altered RNA stability because of the enthalpy-entropy compensation [43].