Regular ArticleIschemic Preconditioning and Morphine-induced Cardioprotection Involve the Delta (δ)-opioid Receptor in the Intact Rat Heart☆
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Impact of timing of morphine treatment on infarct size in experimental animal model of acute myocardial ischemia and reperfusion
2022, European Journal of PharmacologyCitation Excerpt :Although opioid κ and δ receptors dominate the heart (Ventura et al., 1989; Wittert et al., 1996), expressions of opioid μ receptor (MOR), κ receptor (KOR) and δ receptor (DOR) were found in human heart tissues, including the myocardial cells, ICA cells and sensory nerves (Sobanski et al., 2014) and in rat cardiac sarcolemma, intracellular caveolin-3-associated microdomain of adult rat heart (Ventura et al., 1989; Head et al., 2005) and in dorsal root ganglia (Ji et al., 1995; Endres-Becker et al., 2007; Snyder et al., 2018). Here in this study, the cardioprotective effect of morphine was completely reversed by CTAP, norBNI and NTI, indicating that opioid μ, κ and δ receptors were involved in mediation of the cardioprotective effects induced by intravenously injected morphine (0.3 mg/kg) giving at 15 min before induction of myocardial ischemia and reperfusion, as reported previously (Schultz et al., 1995, 1997a, 1997b; Miki et al., 1998; Zhang et al., 2004; Li et al., 2009). Myocardial ischemia may play a role of kick point.
Morphine and myocardial ischaemia-reperfusion
2021, European Journal of PharmacologyCitation Excerpt :Morphine preconditioning (MPC) is initiated by three 5-min or 3-min intravenous drug administrations interspersed with 5-min drug-free periods (Schultz et al., 1996; Wang et al., 1998) or a single intravenous injection of morphine (Gross et al., 2006; Okubo et al., 2004) before prolonged myocardial ischaemia. Opioid receptors (μ-, δ-, κ-opioid receptors) have been shown to be significant triggers or mediators of IPC- or MPC-induced cardioprotection(Gross, 2003; Schultz et al., 1997). Several investigators have further shown that the reduction in infarct size induced by IPC or MPC was mediated by the activation of δ-opioid receptors in the heart to inhibit cardiomyocyte apoptosis in vivo (Okubo et al., 2004; Peart et al., 2003; Schultz et al., 1997).
Opioids and Acute Kidney Injury
2021, Seminars in NephrologyEffects of nalbuphine on the cardioprotective effect of morphine in rats
2021, International Journal of CardiologyProtective transcriptional mechanisms in cardiomyocytes and cardiac fibroblasts
2019, Journal of Molecular and Cellular Cardiology
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Please address all correspondence to: Garrett J. Gross, Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA