Regular ArticleRegulation of Hippocampal Synaptic Plasticity by the Tyrosine Kinase Receptor, REK7/EphA5, and its Ligand, AL-1/Ephrin-A5☆
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Cited by (67)
Repetitive grooming and sensorimotor abnormalities in an ephrin-A knockout model for Autism Spectrum Disorders
2015, Behavioural Brain ResearchCitation Excerpt :Recently, a family of developmental guidance molecules with these capabilities, the A-class Eph receptors and associated ephrins, joined the list with the identification of EPHA3 as an ASD candidate gene [2] and EPHA7 deletions being linked to developmental neurological delays during early childhood [5]. Eph/ephrins are cell-surface molecules with important functions during development, including regulating neuronal migration and sorting [6], topographical organization of neuronal connections [7–10], synaptogenesis [11], and synaptic plasticity [12–16]. Eph receptors and ephrin ligands have A-class and B-class sub-families, which exhibit a hierarchical within class binding specificity, with select members also possessing across-class binding [17].
Eph receptors: New players in Alzheimer's disease pathogenesis
2015, Neurobiology of DiseaseFuture perspectives in nerve repair and regeneration
2013, International Review of NeurobiologyEphrin-A5 deficiency alters sensorimotor and monoaminergic development
2013, Behavioural Brain ResearchCitation Excerpt :In addition, evidence for the involvement of cell adhesion/axon guidance molecules, in ADHD was reported [32,33]. Based on these findings and on the role of ephrin-A5 in neurite outgrowth [17] and targeting of dopaminergic axons [20], these data suggest that loss of ephrin-A5 may result in neurodevelopmental alterations that may contribute to behavioral phenotypes such as the ones observed in ADHD. Many of the core symptoms used for ADHD diagnosis fall under the hyperactivity category.
Contextual learning increases dendrite complexity and EphrinB2 levels in hippocampal mouse neurons
2012, Behavioural Brain ResearchCitation Excerpt :In order to add information on such issue, we investigated possible association of behavioural and cellular modifications induced by fear conditioning in hippocampal and lateral amygdala neurons, to expression of EphrinB2, a cell-adhesion factor known to be strongly expressed in adult brain regions displaying synaptic plasticity [14,15,43], and found to be directly involved in it [14]. Ephrins and Eph receptors belong to a family of tyrosine kinases [44] that cover fundamental roles in the nervous system of vertebrates both during development, by affecting the patterning of axonal connections [45,46,47], and in the adult [6], by modulating, among others, LTP induction [48], the dynamics of dendritic spines [7] and the control of synaptic neuro-glial interactions [49]. EphrinBs, in particular, appear to be involved in both LTP [50] and LTD [13] of hippocampal neuron synapses, and in their maturation process [51], by interaction with their receptors.
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To whom correspondence should be addressed. Fax: (650)-225-6240. E-mail:[email protected].
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Equal senior authorship.