Regular ArticleDifferential Display of Genes Expressed at the Midbrain – Hindbrain Junction Identifies sprouty2: An FGF8-Inducible Member of a Family of Intracellular FGF Antagonists
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2008, Developmental BiologyRole of fibroblast growth factor 8 in growth and progression of hormonal cancer
2007, Cytokine and Growth Factor ReviewsA genetic study of the suppressors of the Engrailed-1 cerebellar phenotype
2007, Brain ResearchCitation Excerpt :This effect can be seen when Fgf8 is expressed ectopically in caudal forebrain explants from mouse embryos (Liu et al., 1999) or when Fgf8-soaked beads are implanted in the caudal diencephalon or midbrain of chick embryos (Crossley et al., 1996; Martinez et al., 1999). Numerous downstream genes have been identified that are induced by Fgf8, including, but not limited to, members of the Engrailed, Pax, and Sprouty families (Crossley et al., 1996; Lee et al., 1997; Liu et al., 1999; Martinez et al., 1999; Minowada et al., 1999; Chambers et al., 2000; Furthauer et al., 2001). Reciprocally, the continued expression of Engrailed-1 and Engrailed-2 is required to sustain the presence of FGF8 (Liu and Joyner, 2001), and, in the developing chick brain, ectopic expression of Engrailed can shift the di-mesencephalic boundary and transform regions of dorsal diencephalon into tectum (Araki and Nakamura, 1999).
Sprouty proteins: Multifaceted negative-feedback regulators of receptor tyrosine kinase signaling
2006, Trends in Cell BiologyModulation of Fgf8 activity during vertebrate brain development
2005, Brain Research ReviewsPostulated boundaries and differential fate in the developing rostral hindbrain
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- 1
Present address: Institute of Psychiatry, King's College London, 1 Windsor Walk, Denmark Hill, London SE5 8AF, UK.
- 2
To whom correspondence should be addressed at the MRC Brain Development Programme, Department of Developmental Neurobiology, King's College London, New Hunt's House, Guy's Campus, London SE1 9RT, UK. E-mail: [email protected].